CCO/OICR Health Services Research Program – Knowledge Translation Research Network Request for Proposals

Funding Partners: CCO/OICR KT Research Network

Project Title:    Knowledge Translation to Address Clinical Challenge Priorities

 Proposal due date:     November 12, 2010

 Notice of decision:     Mid-December 2010

Funding period:   January 2011 to December 2011 (funding may extend to two years)

Funds available:  Funds are available from the CCO/OICR Knowledge Translation Research Network of the Health Services Research Program for projects that address important knowledge translation aspects relevant to the clinical priority areas defined in OICR’s 2010 to 2015 strategic plan (outlined below). Funding available under this initiative is $200,000. Funds are available for projects that are up to $100,000 per year. It is anticipated that 2 or more teams will be funded under this initiative.

While projects that can be completed within one year are preferred, projects can be funded to extend over 2 years (maximum of $100,000 per year) if essential for the viability of the project (see below for application process).  All projects must be completed within the specified time frame.

Application process:  Applications will consist of 5 pages describing the proposal with the following headings:

.     Background

.     Aims

.     A description and explanation of the theoretical underpinning or framework being used, demonstrating its applicability in this context

.     Research design and methods (see details below for field or pilot studies)

.     Outlined plans regarding sustainability. It is understood that the plans will be consistent with the time frame of the proposed project and the amount of resources requested

.     Plans for both integrated and end of grant KT

.     Description of the study team (including any trainees)

.     Timeline (provide a justification if funding is requested for more than one year)

.     Budget

Building on existing projects and/or partnering with organizations that have policy or decision-making responsibilities relevant to the project is encouraged.  Applications to be sent electronically to family.healthcare@utoronto.ca

OICR Clinical Challenge Priorities

OICR’s 2010-2015 Strategic Plan identified five clinical issues as research priorities:

 .     The high fatality of pancreatic cancer

.     The over-diagnosis of prostate cancer

.     The over-aggressive treatment of early stage breast cancer

.     The insufficient participation in population-based screening programs

.     The long-term adverse effects of treatment affecting cancer survivors (with a particular  interest in survivors of childhood, adolescent, and young adult cancers)

 .     Additionally, OICR is also interested in studies involving ‘personalized medicine’

Either field studies or pilot studies relevant to one or more of these clinical challenge priorities will be funded under this initiative.  The details of the project’s relevance to these clinical challenge priorities should be included in the five page application outlined above in “Application Process”.

Objective 1:  Field Studies

 A field study could involve the application of a knowledge translation strategy or approach and should include a clear articulation of the theoretical principles that have led to the project, an evaluation component, and a description of how it may be sustained if successful.

Objective 2:  Pilot Studies

In addition to helping advance understanding of the clinical challenge problem, pilot studies should also include a component about how this work will aid in developing and advancing the fundamental science of KT, a clear articulation of the theoretical principles underlying the study, and a description of how the pilot study will lead to a full scale study in the future.

Knowledge translation (KT)

Applicants are asked to include a description of both integrated KT and end of grant KT in their proposals. It is expected that the successful team will agree to present the research in selected venues of interest to the CCO/OICR Health Services Research Program, including the OICR Annual Scientific Meeting.  Please see the CIHR (http://www.cihr-irsc.gc.ca/e/39033.html) web site for more information on knowledge translation.

 Evaluation of Submissions: Evaluation criteria for both field and pilot studies will include:

 .     The extent to which the application is aligned with an enterprise, currently underway, that would benefit from KT.

.     An explanation of how the study has potential for closing a quality gap in one or more of the clinical priority topics.

.     Why this intervention was chosen? (e.g., how is it situated within the overall literature for this area? How will this study move the field forward?)

.     Strength of the team and is it well placed to form strategic partnerships for both implementation and sustainability of the project.

 Trainees

 Applicants are encouraged to include in their budget support for trainees at any level.  Due to OICR’s translational mandate, there is a preference for supporting clinician-investigators. These trainees are also encouraged to apply for external support, and if successful, the unused money can be retained by the investigators, with justification, to be used in further research or trainee support. In this way the OICR trainee funds can allow investigators to make commitments to trainees while other sources of support are pending.

 Reporting

 Successful applicants will be required to provide quarterly budgets and progress reports, semi-annual scientific progress reports and a full report at the completion of the grant.  The reports should include the following:

 .     Presentations of the supported research.

.     Publications of the supported research.

.     Leveraged funds from other sources related to the supported research.

.     Description of trainees supported (number of trainees, their names, titles, and level) including publications of supported trainees.

 Communication Requirements:

 Grantees will be required to acknowledge CCO and the OICR in all scientific publications or presentations by setting out in any communications materials or publications referencing the research the following statement: “This study was conducted with the support of Cancer Care Ontario and the Ontario Institute for Cancer Research through funding provided by the Government of Ontario.” Grantees must also agree to provide the HSR Program Director with at least 14 days’ notice of any planned communication. As publicly funded organizations, CCO and OICR have a fundamental interest in ensuring the findings resulting from the research it funds are available to the widest possible audience, and at the earliest possible opportunity. Therefore, grantees are also required to deposit all final peer-reviewed full-text manuscripts in the OICR Institutional Repository (OICR-IR) at the time their publication is accepted. This publication can be freely accessible through the Publisher’s website or through the OICR-IR. All publications must be freely accessible within six months of publication.

 Contact Information:

For questions on the funding guidelines, eligibility and how to apply please contact:

 Eva Grunfeld

Director, Knowledge Translation Research Network Cancer Care Ontario and the Ontario Institute of Cancer Research eva.grunfeld@utoronto.ca

 Administrative Assistant: Lindy Chan

Tel: 416.978.7951

Fax: 416.978.3912

family.healthcare@utoronto.ca